https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45080 Wed 26 Oct 2022 11:55:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46862 p < 0.001; R² = 0.0098). Furthermore, when quintiles of ARFS score were tested against each ARCS sub-scale score, statistically significant associations were observed with the greatest effect for the Memory (β = 4.055; p = 0.001; R² = 0.0065) and Attention (β = 4.136; p = 0.002; R² = 0.0047) domains. No statistically significant associations were observed between quintiles of ARFS and MMSE score in the adjusted linear regression analyses. In conclusion, a positive association was observed between diet quality and cognitive performance within this sample of older Australian adults. Further investigation of the above association over time, when follow-up data becomes available, in longitudinal analysis is recommended.]]> Wed 22 Mar 2023 16:38:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29597 Wed 13 Mar 2024 18:28:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13900 Wed 11 Apr 2018 16:11:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37566 Thu 18 Feb 2021 16:15:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40564 Thu 14 Mar 2024 12:19:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38800 Thu 03 Feb 2022 14:59:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31520 Sat 24 Mar 2018 08:43:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28465 Sat 24 Mar 2018 07:39:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34031 Herba cistanche, are known to exert protective effects on cognitive deficits in Alzheimer's disease (AD); however, the underlying mechanisms of this herbal extract on cognitive performance remain unclear. The aim of this study was thus to examine the protective mechanism attributed to PhG on cognitive deficits in an AD senescence accelerated mouse prone 8 (SAMP8) model. Cognitive deficit parameters examined included (1) Morris water maze (MWM) assessing cognitive performance and (2) quantification of dendritic spine density in hippocampal CA1 region by Golgi staining, a molecular biomarker of synaptic function. In addition, levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and gluthathione peroxidase (GSH-Px) were determined to examine the potential role of oxidant processes in cognitive dysfunction. Data showed that PhG significantly decreased escape latency and path length, associated with a rise in the percentage of time spent in the target quadrant and number of platform crossings. In addition, PhG significantly increased dendritic spine density in the hippocampal CA1 region accompanied by elevated expression levels of synaptophysin (SYN) and post synaptic density 95 (PSD-95), reduced MDA content, and elevated the activities of SOD and GSH-Px. Data suggest that the ability of PhG to ameliorate cognitive deficits in SAMP8 mice may be related to promotion in synaptic plasticity involving antioxidant processes.]]> Mon 04 Feb 2019 11:38:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35710 4.5 but <20.0MJ/d). Linear regression models showed statistically significant associations between dietary intake of total n-6 fatty acids and improved cognitive performance measured by the ARCs (RC= 0.0043; P=0.0004; R²= 0.0084). Quartiles of n-6 fatty acid intakes where the lowest quartile of n-6 fatty acid intake (179.8-1150.3mg) and those in the highest quartile (2315.0-7449.4mg) had a total ARCs score 10.6 units greater (RC= 10.60466; P= 0.006; R²= 0.0081). Furthermore, when n-6 fatty acid intake was tested against each of the ARCs domains, statistically significant associations were observed for the Fluency (RC=0.0011432; P= 0.007; R²=0.0057), Visual (RC=0.0009889;P=0.034;R²=0.0050), Language (RC=0.0010651; P=0.047;R²=0.0068) and Attention (RC=0.0011605; P=0.017; R²=0.0099) domains, yet there was no association with Memory (RC= -0.000064; P= 0.889; R²= 0.0083). No statistically significant associations between any other fatty acids and ARCS, nor any fatty acids and MMSE were detected. A higher intake of total n-6 fatty acid, but no other types of fatty acids, was associated with better cognitive performance among a representative sample of older Australian adults.]]> Fri 25 Oct 2019 15:40:12 AEDT ]]>